Liza Maniquis-Smigel, MD
Hawaii Center for Regenerative Medicine – Musculoskeletal Pain, Spine Injury & Neuropathy
As a specialist in Physical Medicine and Rehabilitation (Physiatry), Dr. Liza Maniquis-Smigel approaches healing from a unique, patient-focused perspective dedicated to improving overall quality of life. Her background as a dancer provides her with a distinct understanding of the physical and psychological demands faced by performing artists and athletes. This experience shaped her patient-centered philosophy, enabling her to communicate deeply with those determined to return to their professions after pain and injury. Her advanced training includes a residency in Physical Medicine and Rehabilitation at the University of Illinois Hospital and a fellowship in Musculoskeletal and Performing Arts Medicine, where she honed a holistic treatment methodology.
Dr. Smigel’s expertise is centered on providing advanced non-surgical pain relief for a wide range of conditions. She specializes in diagnosing and treating musculoskeletal injury, complex spine injury, and neuropathy using a sophisticated, integrated approach. Her practice combines traditional interventions, such as physical therapy and mainstream interventional pain procedures, with cutting-edge regenerative medicine techniques. As a certified expert in Orthobiologic Therapy and Platelet Rich Plasma (PRP) treatments, she offers patients innovative options designed to address the root cause of chronic pain and dysfunction.
Dr. Smigel’s mission is to provide compassionate and comprehensive care that addresses the whole person, including the psychological and vocational impacts of their condition. She founded the Hawaii Center for Regenerative Medicine to create a space where patients could access a full spectrum of therapeutic options, from manual therapy and Pilates to advanced orthobiologic procedures. By integrating diverse perspectives gained from collaborating with orthopedic and spine surgeons, she ensures every patient receives a well-rounded and effective treatment plan aimed at achieving lasting health and function.
Genesis® Regenerative Protein Arrays
Genesis® Regenerative Protein Array (RPA) marks a significant step forward in regenerative therapies, representing a generation beyond treatments like PRP. It is estimated to be up to 1,000 times more potent, a factor attributed to its uniquely comprehensive array of over 80 different cytokines, growth factors, and other signaling molecules. This powerful formulation is designed to create an optimal signaling environment that supports the body’s innate capacity for repair and renewal.
The therapy operates by leveraging paracrine signaling. Delivering a complex cocktail of bioactive molecules that send precise instructions to your own cells without introducing new ones. Think of Genesis® RPA not as a new set of construction workers, but as the master architect delivering a new blueprint to help reprogram the local environment of damaged tissues. This process orchestrates your body’s inherent capabilities to manage inflammation, repair damage, and restore functional balance.
A primary advantage of this therapy is its safety profile, as RPA is acellular by design. The product is devoid of any whole cells or DNA, which significantly reduces the risk of adverse reactions or off-target effects. To ensure the highest standards of quality, the arrays are ethically sourced from pristine placentas donated after healthy, scheduled, live c-section births. The product is manufactured in 3rd party FDA-registered facilities and subject to stringent testing protocols, offering the power of regenerative signaling with a reassuring safety profile.
